Enabling A Life Sciences Research Tool
Epigem was contacted by a previous collaborator (now large organisation) looking for support in the design of the fluid-handling components for an optically-based, label-free detection technology for the real-time monitoring of binding interactions between two or more molecules.
Epigem initially partnered with his company in the development of a single flow cell multi-zone demonstration phase. From the outset if was clear that there would be a need to multiplex and miniaturise the high-density microfluidics in a final device, and Epigem was able to demonstrate its capability to meet these requirements, and continued to work with the company to produce a complex multi-layered flow cell with multiple inlets. These enable functionalisation of the detection cell surface, subsequent washing and sample introduction. Precise control of the microfluidic flow is used to generate sheathed flow at multiple points along the flow cell. A key benefit during the development phase was Epigem’s ability to rapidly and cost-effectively prototype design iterations for testing. In the final design the simultaneous injection of multiple samples facilitates high-throughput assay development and optimisation, as well as rapid quantitative analysis of samples. When combined with plate handling robotics thousands of samples can be analysed per day, and the system is commercialised as a Life Sciences research tool as part of the portfolio of a major high-performance scientific instruments manufacturer. Epigem continues to be an important part of their supply chain.
- Collaborative long-term partnership from product concept through commercialisation and company acquisition
- High-density multi-layered microfluidics with a demountable flow-cell interface to the sensor component
- Combination of tens of inlets and outlets addressing the 8 mm x 8 mm sensor footprint.